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Negative room pressure is a segregation method utilized in hospital and industries to keep cross-pollutions from space to room.It incorporates a ventilation that creates negative strain to enable air to stream into the disconnection room yet not escape from the room, as air will normally spill out of regions with higher weight to zones with lower weight, in this manner keeping debased air from getting away from the room. This method is utilized to disconnect patients with airborne infectious illnesses, for example, tuberculosis, measles, or chickenpox.

Negative pressure is produced and kept up by a ventilation framework that expels more fumes air from the room than air is permitted into the room. Air is permitted into the room through a hole under the entryway (commonly around one half-inch high). With the exception of this hole, the room ought to be as water/air proof as would be prudent, permitting no air in through splits and holes, for example, those around windows, light installations and electrical outlets. Spillage from these sources can bargain or take out room negative weight